| Leo R SERIES | ||||
|---|---|---|---|---|
| Leo R1 | Leo R2 | Leo R3 | Leo R4 | Leo R5 |
| Leo R6 | Leo R7 | Leo R8 | Leo R9 | Leo R10 |
| Leo R11 | Leo R12 | Leo R13 | Leo R14 | Leo R15 |
| Leo R16 | Leo R17 | Leo R18 | Leo R19 | Leo R20 |
| Leo R21 | Leo R22 | Leo R23 | Leo R24 | Leo R25 |
Stage-dependent gut microbiome and functional signatures
across the liver disease spectrum:
an integrative multi-cohort study
Key Findings
-
STAGE-DEPENDENT DYSBIOSIS
GUT MICROBIAL DIVERSITY AND COMMUNITY STRUCTURE PROGRESSIVELY DETERIORATED FROM FATTY LIVER TO HEPATOCELLULAR CARCINOMA,
WITH ADVANCED STAGES DOMINATED BY STREPTOCOCCUS AND VEILLONELLA SPP. -
FUNCTIONAL REMODELLING
METABOLIC SIGNATURES EVOLVED FROM ANABOLIC CELL ENVELOPE SYNTHESIS AND TAURINE DEPLETION IN HEPATITIS,
TO TOXIN PRODUCTION (NON-RIBOSOMAL PEPTIDES) AND COMMENSAL FUNCTION LOSS IN CIRRHOSIS,
CULMINATING IN BIOFILM FORMATION AND A PUTATIVE METABOLIC SWITCH IN CARCINOMA. -
DIAGNOSTIC POTENTIAL
MACHINE LEARNING MODELS INTEGRATING MICROBIAL TAXA AND FUNCTIONS ACCURATELY CLASSIFIED LIVER DISEASE STAGES (AUC > 0.8),
SUPPORTING NON-INVASIVE DIAGNOSIS AND RISK STRATIFICATION. -
PROGNOSTIC SIGNIFICANCE
THE EXPANSION OF ORAL-DERIVED VEILLONELLA SPP.
AND THE DOMINANCE OF A LOW-RICHNESS DYSBIOTIC ENTEROTYPE WERE SIGNIFICANTLY ASSOCIATED WITH INCREASED
MORTALITY IN ADVANCED LIVER DISEASE, HIGHLIGHTING THEIR UTILITY AS PREDICTIVE MARKERS FOR CLINICAL OUTCOMES